Abstract Niemann Pick Type-C disease (NPC) is an inherited lysosomal storage disease (LSD) caused by pathogenic variants in the Npc1 or Npc2 genes that lead to the accumulation of cholesterol and lipids in lysosomes.NPC1 deficiency causes neurodegeneration, dementia and early death.Cerebellar Purkinje cells (PCs) are particularly hypersensitive to
Global Disappearance of Tropical Mountain Glaciers: Observations, Causes, and Challenges
This article reviews the current status of tropical glaciers in the South American Andes, East Africa, KARAMBIT and Australasia by shedding light on past, present, and future glacier coverage in the tropics, the influence of global and regional climates on the tropical glaciers, the regional importance of these glaciers, and challenges of ongoing g
Analytical and experimental investigation on the flexural behavior of partially encased composite beams
Composite members have become popular for medium and high rise buildings.This paper presents the results of an experimental and analytical investigation of the partially-encased composite steel beams with and without web openings.The constant parameters included in this study are the cross-sectional area of the specimen, the distribution of web ope
Analysis of Football Referee Satisfaction in Making Decision Based on Experience Levels
The role of a referee is important in every Advanced Wound Care - Antimicrobials football match.A referee sometimes makes mistakes which can affect the outcome of the match.Dissatisfaction with the decision given by a referee will give an impact on the performance shown in a football match.This study aimed to find out the satisfaction of football r